abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

journal_title：British journal of cancer

authors： Linton A,Cheng YY,Griggs K,Schedlich L,Kirschner MB,Gattani S,Srikaran S,Chuan-Hao Kao S,McCaughan BC,Klebe S,van Zandwijk N,Reid G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

journal_title：British journal of cancer

authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

更新日期：2018-03-20 00:00:00

abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

journal_title：British journal of cancer

authors： Ording AG,Veres K,Farkas DK,Adelborg K,Sørensen HT

更新日期：2018-03-20 00:00:00

abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

journal_title：British journal of cancer

authors： Trudel-Fitzgerald C,Zhou ES,Poole EM,Zhang X,Michels KB,Eliassen AH,Chen WY,Holmes MD,Tworoger SS,Schernhammer ES

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...

journal_title：British journal of cancer

authors： Chovanec M,Cierna Z,Miskovska V,Machalekova K,Kalavska K,Rejlekova K,Svetlovska D,Macak D,Spanik S,Kajo K,Babal P,De Giorgi U,Mego M,Mardiak J

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:We investigated whether pazopanib maintenance following first-line chemotherapy would improve survival in patients with extensive disease small-cell lung cancer (ED-SCLC). METHODS:This study is a randomised, placebo-controlled, phase II study that enroled ED-SCLC patients who had not progressed after four c...

journal_title：British journal of cancer

authors： Sun JM,Lee KH,Kim BS,Kim HG,Min YJ,Yi SY,Yun HJ,Jung SH,Lee SH,Ahn JS,Park K,Ahn MJ

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...

journal_title：British journal of cancer

authors： Nossiter J,Sujenthiran A,Charman SC,Cathcart PJ,Aggarwal A,Payne H,Clarke NW,van der Meulen J

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Cutaneous melanoma is the most serious skin malignancy and new therapeutic strategies are needed for advanced melanoma. TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strategy in cutaneous melanoma. Here, we investigated the WIP1 inhibitor, GSK2...

journal_title：British journal of cancer

authors： Wu CE,Esfandiari A,Ho YH,Wang N,Mahdi AK,Aptullahoglu E,Lovat P,Lunec J

更新日期：2018-02-20 00:00:00

abstract：:The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...

journal_title：British journal of cancer

authors： Brown JS,Sundar R,Lopez J

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS:We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC)...

journal_title：British journal of cancer

authors： Häyry V,Kågedal Å,Hjalmarsson E,Neves da Silva PF,Drakskog C,Margolin G,Georén SK,Munck-Wikland E,Winqvist O,Cardell LO

更新日期：2018-02-06 00:00:00

abstract：:This corrects the article DOI: 10.1038/bjc.2017.327. ...

journal_title：British journal of cancer

authors： Infante JR,Korn RL,Rosen LS,LoRusso P,Dychter SS,Zhu J,Maneval DC,Jiang P,Shepard HM,Frost G,Von Hoff DD,Borad MJ,Ramanathan RK

更新日期：2018-01-01 00:00:00

abstract：:Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...

journal_title：British journal of cancer

authors： Staudacher AH,Brown MP

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...

journal_title：British journal of cancer

authors： Pesola F,Ferlay J,Sasieni P

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer. METHODS:In an initial screen of ANOs, ANO9/TMEM16J was overexpressed in pan...

journal_title：British journal of cancer

authors： Jun I,Park HS,Piao H,Han JW,An MJ,Yun BG,Zhang X,Cha YH,Shin YK,Yook JI,Jung J,Gee HY,Park JS,Yoon DS,Jeung HC,Lee MG

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Prostate cancer is the most common cancer in British men but its aetiology is not well understood. We aimed to identify risk factors for prostate cancer in British males. METHODS:We studied 219 335 men from the UK Biobank study who were free from cancer at baseline. Exposure data were collected at recruitme...

journal_title：British journal of cancer

authors： Perez-Cornago A,Key TJ,Allen NE,Fensom GK,Bradbury KE,Martin RM,Travis RC

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern ...

journal_title：British journal of cancer

authors： van Dam PJ,van der Stok EP,Teuwen LA,Van den Eynden GG,Illemann M,Frentzas S,Majeed AW,Eefsen RL,Coebergh van den Braak RRJ,Lazaris A,Fernandez MC,Galjart B,Laerum OD,Rayes R,Grünhagen DJ,Van de Paer M,Sucaet Y,Mudhar H

更新日期：2017-11-07 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significa...

journal_title：British journal of cancer

authors： Cassier PA,Castets M,Belhabri A,Vey N

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS:PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve...

journal_title：British journal of cancer

authors： Shi F,Zhang Q,Liang Z,Zhang M,Liu X

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:First Spanish trial of Ewing sarcoma (ES) including adults and children with the aim to test the efficacy of Gemcitabine and Docetaxel (G/D) in newly diagnosed high-risk (HR) patients. METHODS:This was a prospective, multicentric, non-randomised, open study for patients ⩽40 years with newly diagnosed ES. HR...

journal_title：British journal of cancer

authors： Mora J,Castañeda A,Perez-Jaume S,Lopez-Pousa A,Maradiegue E,Valverde C,Martin-Broto J,Garcia Del Muro X,Cruz O,Cruz J,Martinez-Trufero J,Maurel J,Vaz MA,de Alava E,de Torres C

更新日期：2017-09-05 00:00:00

abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

journal_title：British journal of cancer

authors： Barnes TA,Amir E

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. We evaluated the prognostic significance of candidate cytokines and angiogenic factors (CAFs) identified in ...

journal_title：British journal of cancer

authors： Zurita AJ,Gagnon RC,Liu Y,Tran HT,Figlin RA,Hutson TE,D'Amelio AM Jr,Sternberg CN,Pandite LN,Heymach JV

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:Gene mutations in the RAS family rule out metastatic colorectal carcinomas (mCRCs) from anti-EGFR therapies. METHODS:We report a retrospective analysis by Sequenom Massarray and fast COLD-PCR followed by Sanger sequencing on 240 mCRCs. RESULTS:By Sequenom, KRAS and NRAS exons 2-3-4 were mutated in 52.9% (1...

journal_title：British journal of cancer

authors： Mariani S,Bertero L,Osella-Abate S,Di Bello C,Francia di Celle P,Coppola V,Sapino A,Cassoni P,Marchiò C

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:The Dutch guidelines advise to start radiation therapy (RT) within 5 weeks following breast-conserving surgery (BCS). However, much controversy exists regarding timing of RT. This study investigated its effect on 10-year disease-free survival (DFS) in a Dutch population-based cohort. METHODS:All women diagn...

journal_title：British journal of cancer

authors： van Maaren MC,Bretveld RW,Jobsen JJ,Veenstra RK,Groothuis-Oudshoorn CG,Struikmans H,Maduro JH,Strobbe LJ,Poortmans PM,Siesling S

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Pancreatic cancer is highly malignant and characterised by rapid and uncontrolled growth. While some of the important regulatory networks involved in pancreatic cancer have been determined, the cancer relevant genes have not been fully identified. METHODS:We screened genes that may control proliferation in ...

journal_title：British journal of cancer

authors： Wang J,Guo X,Xie C,Jiang J

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20-30% of patients. Drug repurposing for anti-cancer treatments is gaining momentum, but the potential...

journal_title：British journal of cancer

authors： Gash KJ,Chambers AC,Cotton DE,Williams AC,Thomas MG

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS:Eligible patients received continuous cycles of combination thera...

journal_title：British journal of cancer

authors： Kim R,Chiorean EG,Amin M,Rocha-Lima CMS,Gandhi J,Harris WP,Song T,Portnoy D

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS:We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adeno...

journal_title：British journal of cancer

authors： Strell C,Norberg KJ,Mezheyeuski A,Schnittert J,Kuninty PR,Moro CF,Paulsson J,Schultz NA,Calatayud D,Löhr JM,Frings O,Verbeke CS,Heuchel RL,Prakash J,Johansen JS,Östman A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:RSPO ligands, activators of the Wnt/β-catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). METHODS:Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT-PCR. ...

journal_title：British journal of cancer

authors： Coussy F,Lallemand F,Vacher S,Schnitzler A,Chemlali W,Caly M,Nicolas A,Richon S,Meseure D,El Botty R,De-Plater L,Fuhrmann L,Dubois T,Roman-Roman S,Dangles-Marie V,Marangoni E,Bièche I

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Pre-existing non-cancer conditions may complicate and delay colorectal cancer diagnosis. METHOD:Incident cases (aged ⩾40 years, 2007-2009) with colorectal cancer were identified in the Clinical Practice Research Datalink, UK. Diagnostic interval was defined as time from first symptomatic presentation of col...

journal_title：British journal of cancer

authors： Mounce LTA,Price S,Valderas JM,Hamilton W

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:To evaluate safety, pharmacokinetics, and maximum tolerated dose of roniciclib in patients with advanced malignancies, with dose expansion to evaluate clinical benefit at the recommended phase II dose (RP2D). METHODS:Two phase I dose-escalation studies evaluated two roniciclib dosing schedules: 3 days on/4 ...

journal_title：British journal of cancer

authors： Bahleda R,Grilley-Olson JE,Govindan R,Barlesi F,Greillier L,Perol M,Ray-Coquard I,Strumberg D,Schultheis B,Dy GK,Zalcman G,Weiss GJ,Walter AO,Kornacker M,Rajagopalan P,Henderson D,Nogai H,Ocker M,Soria JC

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...

journal_title：British journal of cancer

authors： Papadakis ES,Reeves T,Robson NH,Maishman T,Packham G,Cutress RI

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and...

journal_title：British journal of cancer

authors： Pruikkonen S,Kallio MJ

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...

journal_title：British journal of cancer

authors： Freisling H,Arnold M,Soerjomataram I,O'Doherty MG,Ordóñez-Mena JM,Bamia C,Kampman E,Leitzmann M,Romieu I,Kee F,Tsilidis K,Tjønneland A,Trichopoulou A,Boffetta P,Benetou V,Bueno-de-Mesquita HBA,Huerta JM,Brenner H,Wils

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Cabazitaxel is approved for treatment of castration-resistant metastatic prostate cancer. The current dosing strategy of cabazitaxel is based on body surface area (BSA). Body surface area is known as a poor predictor for total systemic exposure to drugs, since it does not take into account variability in act...

journal_title：British journal of cancer

authors： Janssen A,Verkleij CPM,van der Vlist A,Mathijssen RHJ,Bloemendal HJ,Ter Heine R

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

journal_title：British journal of cancer

authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...

journal_title：British journal of cancer

authors： Han S,Meng L,Jiang Y,Cheng W,Tie X,Xia J,Wu A

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS:Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosi...

journal_title：British journal of cancer

authors： Dixon SC,Nagle CM,Wentzensen N,Trabert B,Beeghly-Fadiel A,Schildkraut JM,Moysich KB,deFazio A,Australian Ovarian Cancer Study Group.,Risch HA,Rossing MA,Doherty JA,Wicklund KG,Goodman MT,Modugno F,Ness RB,Edwards RP,Jen

更新日期：2017-04-25 00:00:00

abstract：BACKGROUND:Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration. METHODS:A systematic review and meta-analysis of pape...

journal_title：British journal of cancer

authors： Vaughan-Shaw PG,O'Sullivan F,Farrington SM,Theodoratou E,Campbell H,Dunlop MG,Zgaga L

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...

journal_title：British journal of cancer

authors： Xu L,Zhu Y,Shao J,Chen M,Yan H,Li G,Zhu Y,Xu Z,Yang B,Luo P,He Q

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. METHODS:We identified 545 women with...

journal_title：British journal of cancer

authors： Begg CB,Rice MS,Zabor EC,Tworoger SS

更新日期：2017-04-11 00:00:00